Wechselwirkungen · Imbruvica
IMBRUVICA 140 mg film-coated tablets IMBRUVICA 280 mg film-coated tablets IMBRUVICA 420 mg film-coated tablets IMBRUVICA 560 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 52
HOS-131646 · Präparat HOS-097103
Ibrutinib has a pH dependent solubility, with lower solubility at higher pH. A lower Cmax was observed in fasted healthy subjects administered a single 560 mg dose of ibrutinib after taking omeprazole at 40 mg once daily for 5 days (see section 5.2). There is no evidence that the lower Cmax would have clinical significance, and medicinal products that increase stomach pH (e.g., proton pump inhibitors) have been used without restrictions in the pivotal clinical studies.
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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ibrutinib (HOS-086226) omeprazole (HOS-085912)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-07T15:30:00Z · SHA-256 a9cee31168a81381e2e0315390c7e6008548b2272679979bce5eb1784595366b · Passage 1e830f724f5dbdddca9c775da0fb738cf32fb687cd9f530c453dc8e84ead9fd9 · Zeichen 3579–4052 im Abschnitt