Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Keytruda

KEYTRUDA 395 mg solution for injection KEYTRUDA 790 mg solution for injection · Abschnitt 4.8 · PDF-Seite 177–178

HOS-131854 · Präparat HOS-097138

177 MedDRA SOC Monotherapy In combination with In combination with and frequency chemotherapy, axitinib or lenvatinib category radiation therapy or chemoradiotherapy Metabolism and nutrition disorders Very common decreased appetite hypokalaemia, decreased decreased appetite appetite Common hyponatraemia, hyponatraemia, hyponatraemia, hypokalaemia, hypocalcaemia hypokalaemia, hypocalcaemia hypocalcaemia Uncommon type 1 diabetes type 1 diabetes mellitus⁎ type 1 diabetes mellitus⁎ mellitus⁎ Psychiatric disorders Very common insomnia Common insomnia insomnia Nervous system disorders Very common headache neuropathy peripheral, headache, dysgeusia headache Common dizziness, dizziness, dysgeusia dizziness, neuropathy neuropathy peripheral, lethargy peripheral, lethargy, dysgeusia Uncommon myasthenic encephalitis⁎, lethargy myasthenic syndrome⁎¶, epilepsy syndrome⁎¶, encephalitis⁎ Rare Guillain-Barré myasthenic syndrome⁎¶, optic neuritis syndrome⁎, Guillain-Barré encephalitis⁎, syndrome⁎, myelitis, myelitis⁎, optic optic neuritis, epilepsy, neuritis, meningitis meningitis (aseptic) (aseptic)⁎ Eye disorders Common dry eye dry eye dry eye Uncommon uveitis⁎ uveitis⁎ uveitis⁎ Rare Vogt-Koyanagi-Har Vogt-Koyanagi-Harad ada syndrome a syndrome Cardiac disorders Common cardiac arrhythmia‡ cardiac arrhythmia‡ cardiac arrhythmia‡ (including atrial (including atrial (including atrial fibrillation) fibrillation) fibrillation) Uncommon myocarditis¶, myocarditis⁎¶, myocarditis¶, pericarditis⁎, pericarditis⁎, pericardial pericardial effusion pericardial effusion effusion Vascular disorders Very common hypertension Common hypertension hypertension Uncommon vasculitis⁎ vasculitis⁎ Rare vasculitis⁎

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