Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Zydelig

Zydelig 100 mg film-coated tablets Zydelig 150 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7–8

HOS-132102 · Präparat HOS-097192

7 Medicinal product Expected effect of Clinical recommendation upon idelalisib on medicinal co-administration with idelalisib product levels ANTICOAGULANTS Warfarin ↑ serum concentrations It is recommended that the international normalised ratio (INR) be monitored upon co-administration and following ceasing treatment with idelalisib. ANTICONVULSANTS Carbamazepine ↑ serum concentrations Anticonvulsant medicinal product levels should be monitored. ANTIDEPRESSANTS Trazodone ↑ serum concentrations Careful dose titration of the antidepressant and monitoring for antidepressant response is recommended. ANTI-GOUT Colchicine ↑ serum concentrations Dose reductions of colchicine may be required. Idelalisib should not be co-administered with colchicine to patients with renal or hepatic impairment. ANTI-HYPERTENSIVES Amlodipine, diltiazem, ↑ serum concentrations Clinical monitoring of therapeutic felodipine, nifedipine, effect and adverse reactions is nicardipine recommended. ANTI-INFECTIVES Antifungals Ketoconazole, itraconazole, ↑ serum concentrations Clinical monitoring is recommended. posaconazole, voriconazole Antimycobacterials Rifabutin ↑ serum concentrations Increased monitoring for rifabutin- associated adverse reactions including neutropenia and uveitis is recommended. HCV protease inhibitors Boceprevir, telaprevir ↑ serum concentrations Clinical monitoring is recommended. Macrolide antibiotics Clarithromycin, telithromycin ↑ serum concentrations No dose adjustment of clarithromycin is required for patients with normal renal function or mild renal impairment (creatinine clearance [CrCl] 60-90 mL/min). Clinical monitoring is recommended for patients with CrCl < 90 mL/min. For patients with CrCl < 60 mL/min, alternative antibacterials should be considered.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): diltiazem (HOS-086288) nifedipine (HOS-086289) nicardipine (HOS-090619) protease (HOS-085623) ketoconazole (HOS-084513) felodipine (HOS-108908) carbamazepine (HOS-085618) rifabutin (HOS-086262) amlodipine (HOS-086287) creatinine (HOS-086273) voriconazole (HOS-084524) telaprevir (HOS-090618) telithromycin (HOS-084523) itraconazole (HOS-084516) trazodone (HOS-086251) boceprevir (HOS-090617) clarithromycin (HOS-084517) colchicine (HOS-086147) warfarin (HOS-085950) posaconazole (HOS-085622)