Wechselwirkungen · Briviact (in Italy: Nubriveo)
Briviact 10 mg/ml solution for injection/infusion · Abschnitt 4.5 · PDF-Seite 43
HOS-132807 · Präparat HOS-097290
Table 1: Pharmacokinetic interactions between brivaracetam and other AEDs AED coadministered Influence of AED on brivaracetam Influence of brivaracetam on plasma concentration AED plasma concentration Carbamazepine AUC 29 % ↓ Carbamazepine - None Cmax 13 % ↓ Carbamazepine-epoxide ↑ No dose adjustment required (See below) No dose adjustment required. Clobazam No data available None Clonazepam No data available None Lacosamide No data available None Lamotrigine None None Levetiracetam None None Oxcarbazepine None None (monohydroxy derivative, MHD) Phenobarbital AUC 19 % ↓ None No dose adjustment required Phenytoin AUC 21 % ↓ None a No dose adjustment required AUC 20% ↑ a Cmax 20% ↑ Pregabalin No data available None Topiramate None None Valproic acid None None Zonisamide No data available None a based on a study involving the administration of a supratherapeutic dose of 400 mg/day brivaracetam
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lamotrigine (HOS-086242) pregabalin (HOS-112893) zonisamide (HOS-113349) topiramate (HOS-110310) phenobarbital (HOS-085617) valproic acid (HOS-088515) carbamazepine (HOS-085618) clonazepam (HOS-116372) lacosamide (HOS-119434) clobazam (HOS-115305) oxcarbazepine (HOS-110224) phenytoin (HOS-084531) levetiracetam (HOS-090742)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-05-19T16:24:00Z · SHA-256 8b43e201402e087df36cd28aad896b8b68dd1973b788cdf0991029210330f8cc · Passage a85359f86ddb15f4c003c78da49ccc7749096d8a1fb461df879c4788092ede93 · Zeichen 4263–6365 im Abschnitt