Wechselwirkungen · Duloxetine Zentiva
Duloxetine Zentiva 30 mg gastro-resistant hard capsules Duloxetine Zentiva 60 mg gastro-resistant hard capsules · Abschnitt 4.5 · PDF-Seite 8
HOS-133014 · Präparat HOS-097350
Medicinal products metabolised by CYP2D6 Duloxetine is a moderate inhibitor of CYP2D6. When duloxetine was administered at a dose of 60 mg twice daily with a single dose of desipramine, a CYP2D6 substrate, the AUC of desipramine increased 3-fold. The co-administration of duloxetine (40 mg twice daily) increases steady state AUC of tolterodine (2 mg twice daily) by 71 %, but does not affect the pharmacokinetics of its active 5- hydroxyl metabolite and no dosage adjustment is recommended. Caution is advised if duloxetine is co- administered with medicinal products that are predominantly metabolised by CYP2D6 (risperidone,
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tolterodine (HOS-087792) desipramine (HOS-086249) risperidone (HOS-086280)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-11-29T16:00:00Z · SHA-256 a6188d2978ea09f7e5b7445a447f5e2a57efdecb0d31b2c6eef34f98353221c3 · Passage 052d36e07670b6a346a0c99f6a16088cd8966146a02a552f01abdb66b616ad6e · Zeichen 2365–2992 im Abschnitt