Nebenwirkungen · Cotellic
Cotellic 20 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 11
HOS-133182 · Präparat HOS-097388
In Study GO28141, the most common adverse reactions (>20%) observed with a higher frequency in the Cotellic plus vemurafenib arm were diarrhoea, rash, nausea, pyrexia, photosensitivity reaction, increased alanine aminotransferase, increased aspartate aminotransferase, increased blood creatine phosphokinase, and vomiting. The most common adverse reactions (>20%) observed with a higher frequency in the placebo plus vemurafenib arm were arthralgia, alopecia, and hyperkeratosis. Fatigue was observed at similar frequencies in both arms.
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Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-06-24T11:11:11Z · SHA-256 f1f2b0f1a6369a0b0850f74c6ba5e720545731feab9d3f2f0d55fff6ff804055 · Passage 9c15dccabb45f5c861fc69b66673358d5d6199b7878817dba5b9c2bd7007f913 · Zeichen 589–1126 im Abschnitt