Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Bortezomib Accord

Bortezomib Accord 1 mg powder for solution for injection Bortezomib Accord 3.5 mg powder for solution for injection · Abschnitt 4.8 · PDF-Seite 47–48

HOS-133319 · Präparat HOS-097412

47 System Organ Class Incidence Adverse reaction Neoplasms Rare Neoplasm malignant, Leukaemia plasmacytic, Renal cell benign, malignant carcinoma, Mass, Mycosis fungoides, Neoplasm benign* and unspecified (incl cysts and polyps) Blood and Very Common Thrombocytopenia*, Neutropenia*, Anaemia* lymphatic system Common Leukopenia*, Lymphopenia* disorders Uncommon Pancytopenia*, Febrile neutropenia, Coagulopathy*, Leukocytosis*, Lymphadenopathy, Haemolytic anaemia# Rare Disseminated intravascular coagulation, Thrombocytosis*, Hyperviscosity syndrome, Platelet disorder NOS, Thrombotic microangiopathy (inc thrombocytopenic purpura) #, Blood disorder NOS, Haemorrhagic diathesis, Lymphocytic infiltration Immune system Uncommon Angioedema#, Hypersensitivity* disorders Rare Anaphylactic shock, Amyloidosis, Type III immune complex mediated reaction Endocrine Uncommon Cushing's syndrome*, Hyperthyroidism*, Inappropriate disorders antidiuretic hormone secretion Rare Hypothyroidism Metabolism and Very Common Decreased appetite nutrition disorders Common Dehydration, Hypokalaemia*, Hyponatraemia*, Blood glucose abnormal*, Hypocalcaemia*, Enzyme abnormality* Uncommon Tumour lysis syndrome, Failure to thrive*, Hypomagnesaemia*, Hypophosphataemia*, Hyperkalaemia*, Hypercalcaemia*, Hypernatraemia*, Uric acid abnormal*, Diabetes mellitus*, Fluid retention Rare Hypermagnesaemia*, Acidosis, Electrolyte imbalance*, Fluid overload, Hypochloraemia*, Hypovolaemia, Hyperchloraemia*, Hyperphosphataemia*, Metabolic disorder, Vitamin B complex deficiency, Vitamin B12 deficiency, Gout, Increased appetite, Alcohol intolerance Psychiatric Common Mood disorders and disturbances*, Anxiety disorder*, Sleep disorders disorders and disturbances* Uncommon Mental disorder*, Hallucination*, Psychotic disorder*, Confusion*, Restlessness Rare Suicidal ideation*, Adjustment disorder, Delirium, Libido decreased Nervous system Very Common Neuropathies*, Peripheral sensory neuropathy, Dysaesthesia*, disorders Neuralgia* Common Motor neuropathy*, Loss of consciousness (inc syncope), Dizziness*, Dysgeusia*, Lethargy, Headache* Uncommon Tremor, Peripheral sensorimotor neuropathy, Dyskinesia*, Cerebellar coordination and balance disturbances*, Memory loss (exc dementia)*, Encephalopathy*, Posterior Reversible Encephalopathy Syndrome#, Neurotoxicity, Seizure disorders*, Post herpetic neuralgia, Speech disorder*, Restless legs syndrome, Migraine, Sciatica, Disturbance in attention, Reflexes abnormal*, Parosmia

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