Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Opdivo

OPDIVO 10 mg/mL concentrate for solution for infusion. · Abschnitt 4.8 · PDF-Seite 30–31

HOS-133365 · Präparat HOS-097426

30  Combination with Combination with Combination with ipilimumab (with or chemotherapy cabozantinib without chemotherapy) Metabolism and nutrition disorders Very common decreased appetite, decreased appetite, decreased appetite, hyperglycaemiab, hyperglycaemiab, hypoglycaemiab, hypoglycaemiab hypoglycaemiab hyperglycaemiab, weight decreased Common dehydration, hypoalbuminaemia, dehydration hypoalbuminaemia, hypophosphataemia hypophosphataemia, weight decreased Uncommon metabolic acidosis Rare tumour lysis syndrome h Not known tumour lysis syndrome Nervous system disorders Very common headache peripheral neuropathy dysgeusia, dizziness, headache Common dizziness, peripheral paraesthesia, dizziness, peripheral neuropathy neuropathy headache Uncommon polyneuropathy, peroneal Guillain-Barré syndrome encephalitis autoimmune, nerve palsy, autoimmune Guillain-Barré syndrome, neuropathy (including myasthenic syndrome facial and abducens nerve paresis), encephalitis, myasthenia gravis, Myocarditis-Myositis- Myasthenia Gravis Overlap Syndromel Rare Guillain-Barré syndrome, encephalitis, neuritis, myelitis (including Myocarditis-Myositis- transverse myelitis), optic Myasthenia Gravis neuritis Overlap Syndromel Not known myelitis (including Myocarditis-Myositis- transverse myelitis), Myasthenia Gravis Overlap optic neuritis Syndromel Ear and labyrinth disorders Common tinnitus Eye disorders Common blurred vision, dry eye dry eye, blurred vision dry eye, blurred vision Uncommon uveitis, episcleritis uveitis uveitis Rare Vogt-Koyanagi-Harada syndrome Cardiac disorders Common tachycardia, atrial tachycardia, atrial atrial fibrillation, tachycardia fibrillation fibrillation Uncommon myocarditisa, arrhythmia myocarditis myocarditis (including ventricular arrhythmia)a, bradycardia Not known pericardial disordersi Vascular disorders Very common hypertension a, k Common hypertension thrombosis , thrombosisk hypertension, vasculitis

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.