Nebenwirkungen · Opdivo
OPDIVO 300 mg solution for injection OPDIVO 600 mg solution for injection · Abschnitt 4.8 · PDF-Seite 173
HOS-133475 · Präparat HOS-097426
In patients treated with nivolumab in combination with cabozantinib, the incidence of diarrhoea, colitis, frequent bowel movements or enteritis was 59.1% (189/320). Grade 2 and Grade 3 cases were reported in 25.6% (82/320) and 6.3% (20/320) of patients, respectively. Grade 4 were reported in 0.6% (2/320). Median time to onset was 12.9 weeks (range: 0.3-110.9 weeks). Resolution occurred in 143 patients (76.1%) with a median time to resolution of 12.9 weeks (range: 0.1-139.7+ weeks).
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Version 2026-08-19T11:11:00Z · SHA-256 1ce21ede7b3b9a8abc396626f301d2db3510ede7261a38fc34a275e7a180f454 · Passage 29fa6c3c4492cb38eaea23a1537821bf41b120c75f604ffaed1a48cf96c6408f · Zeichen 38974–39460 im Abschnitt