Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)

Darunavir Viatris 75 mg film-coated tablets Darunavir Viatris 150 mg film-coated tablets Darunavir Viatris 300 mg film-coated tablets Darunavir Viatris 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 13

HOS-134490 · Präparat HOS-097580

Amiodarone Darunavir co-administered with low Bepridil dose ritonavir and amiodarone, Dronedarone bepridil, dronedarone, ivabradine, Ivabradine, quinidine, or ranolazine is Quinidine contraindicated (see section 4.3). Ranolazine Digoxin digoxin AUC ↑ 61% Given that digoxin has a narrow 0.4 mg single dose digoxin Cmin ND therapeutic index, it is digoxin Cmax ↑ 29% recommended that the lowest (↑ digoxin from probable inhibition of possible dose of digoxin should P-gp) initially be prescribed in case digoxin is given to patients on darunavir/ritonavir therapy. The digoxin dose should be carefully titrated to obtain the desired clinical effect while assessing the overall clinical state of the subject. ANTIBIOTIC clarithromycin AUC ↑ 57% Clarithromycin 500 mg Caution should be exercised when twice daily clarithromycin Cmin ↑ 174% clarithromycin is combined with clarithromycin Cmax ↑ 26% darunavir co-administered with low # darunavir AUC ↓ 13% dose ritonavir. # darunavir Cmin ↑ 1% # darunavir Cmax ↓ 17% For patients with renal impairment the Summary of Product 14-OH-clarithromycin concentrations Characteristics for clarithromycin were not detectable when combined should be consulted for the with darunavir/ritonavir. recommended dose. (↑ clarithromycin from CYP3A inhibition and possible P-gp inhibition) ANTICOAGULANT/PLATELET AGGREGATION INHIBITOR Apixaban Not studied. Co-administration of The use of boosted darunavir with a Rivaroxaban boosted darunavir with these direct anticoagulant (DOAC) that is anticoagulants may increase metabolized by CYP3A4 and concentrations of the anticoagulant. transported by P-gp is not (CYP3A and/or P-gp inhibition). recommended as this may lead to an increased bleeding risk.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): dronedarone (HOS-086144) bepridil (HOS-085612) quinidine (HOS-085593) digoxin (HOS-086172) rivaroxaban (HOS-086236) lead (HOS-085592) clarithromycin (HOS-084517) apixaban (HOS-112091) ivabradine (HOS-109426) ritonavir (HOS-084521) amiodarone (HOS-085596) ranolazine (HOS-086141)