Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)

Darunavir Viatris 75 mg film-coated tablets Darunavir Viatris 150 mg film-coated tablets Darunavir Viatris 300 mg film-coated tablets Darunavir Viatris 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 14

HOS-134492 · Präparat HOS-097580

Clopidogrel Not studied. Co-administration of Co-administration of clopidogrel clopidogrel with boosted darunavir is with boosted darunavir is not expected to decrease clopidogrel active recommended. metabolite plasma concentration, which may reduce the antiplatelet Use of other antiplatelets not activity of clopidogrel. affected by CYP inhibition or induction (e.g. prasugrel) is recommended. Warfarin Not studied. Warfarin concentrations It is recommended that the may be affected when co-administered international normalised ratio (INR) with darunavir with low dose ritonavir. be monitored when warfarin is combined with darunavir co- administered with low dose ritonavir. ANTICONVULSANTS Phenobarbital Not studied. Phenobarbital and Darunavir co-administered with low Phenytoin phenytoin are expected to decrease dose ritonavir should not be used in plasma concentrations of darunavir and combination with these medicines. its pharmacoenhancer. (induction of CYP450 enzymes) Carbamazepine carbamazepine AUC ↑ 45% No dose adjustment for 200 mg twice daily carbamazepine Cmin ↑ 54% darunavir/ritonavir is carbamazepine Cmax ↑ 43% recommended. If there is a need to darunavir AUC ↔ combine darunavir/ritonavir and darunavir Cmin ↓ 15% carbamazepine, patients should be darunavir Cmax ↔ monitored for potential carbamazepine-related adverse events. Carbamazepine concentrations should be monitored and its dose should be titrated for adequate response. Based upon the findings, the carbamazepine dose may need to be reduced by 25% to 50% in the presence of darunavir/ritonavir. Clonazepam Not studied. Co-administration of Clinical monitoring is boosted darunavir with clonazepam recommended when co- may increase concentrations of administering boosted darunavir clonazepam. (CYP3A inhibition) with clonazepam.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) carbamazepine (HOS-085618) clonazepam (HOS-116372) clopidogrel (HOS-087927) prasugrel (HOS-112066) ritonavir (HOS-084521) phenytoin (HOS-084531) warfarin (HOS-085950)