Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)

Darunavir Viatris 400 mg film-coated tablets Darunavir Viatris 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 57

HOS-134621 · Präparat HOS-097580

Amitriptyline Concomitant use of boosted Clinical monitoring is recommended Desipramine darunavir and these antidepressants when co-administering boosted Imipramine may increase concentrations of the darunavir with these antidepressants Nortriptyline antidepressant. and a dose adjustment of the Trazodone (CYP2D6 and/or CYP3A antidepressant may be needed. inhibition) ANTI-DIABETICS Metformin Not studied. Based on theoretical Careful patient monitoring and dose considerations darunavir co- adjustment of metformin is administered with cobicistat is recommended in patients who are expected to increase metformin taking darunavir co-administered plasma concentrations. with cobicistat. (MATE1 inhibition) (not applicable for darunavir co- administered with ritonavir) ANTIEMETICS Domperidone Not studied. Co-administration of domperidone with boosted darunavir is contraindicated. ANTIFUNGALS Voriconazole Not studied. Ritonavir may Voriconazole should not be decrease plasma concentrations of combined with boosted darunavir voriconazole. unless an assessment of the (induction of CYP450 enzymes) benefit/risk ratio justifies the use of voriconazole. Concentrations of voriconazole may increase or decrease when co- administered with darunavir co- administered with cobicistat. (inhibition of CYP450 enzymes)

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): nortriptyline (HOS-086245) amitriptyline (HOS-085911) desipramine (HOS-086249) imipramine (HOS-085907) cobicistat (HOS-088111) domperidone (HOS-114656) voriconazole (HOS-084524) trazodone (HOS-086251) ritonavir (HOS-084521) metformin (HOS-091032)