Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)

Darunavir Viatris 400 mg film-coated tablets Darunavir Viatris 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 59–60

HOS-134627 · Präparat HOS-097580

59 INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS Medicinal products by Interaction Recommendations concerning co- therapeutic areas Geometric mean change (%) administration Perphenazine Not studied. Boosted darunavir is A dose decrease may be needed for Risperidone expected to increase these these drugs when co-administered Thioridazine antipsychotic plasma with boosted darunavir. concentrations. (CYP3A, CYP2D6 and/or P-gp inhibition) Lurasidone Concomitant administration of Pimozide boosted darunavir and lurasidone, Sertindole pimozide or sertindole is contraindicated (see section 4.3). β-BLOCKERS Carvedilol Not studied. Boosted darunavir is Clinical monitoring is recommended Metoprolol expected to increase these β-blocker when co-administering boosted Timolol plasma concentrations. darunavir with β-blockers. A lower (CYP2D6 inhibition) dose of the β-blocker should be considered. CALCIUM CHANNEL BLOCKERS Amlodipine Not studied. Boosted darunavir can Clinical monitoring of therapeutic Diltiazem be expected to increase the plasma and adverse effects is recommended Felodipine concentrations of calcium channel when these medicines are Nicardipine blockers. concomitantly administered with Nifedipine (CYP3A and/or CYP2D6 boosted darunavir. Verapamil inhibition) CORTICOSTEROIDS Corticosteroids primarily Fluticasone: in a clinical study Concomitant use of boosted metabolised by CYP3A where ritonavir 100 mg capsules darunavir and corticosteroids (all (including betamethasone, twice daily were co-administered routes of administration) that are budesonide, fluticasone, with 50 μg intranasal fluticasone metabolised by CYP3A may increase mometasone, prednisone, propionate (4 times daily) for 7 the risk of development of systemic triamcinolone) days in healthy subjects, fluticasone corticosteroid effects, including propionate plasma concentrations Cushing’s syndrome and adrenal increased significantly, whereas the suppression. intrinsic cortisol levels decreased by approximately 86% (90% CI 82- Co-administration with CYP3A- 89%). Greater effects may be metabolised corticosteroids is not expected when fluticasone is recommended unless the potential inhaled. Systemic corticosteroid benefit to the patient outweighs the effects including Cushing's risk, in which case patients should be syndrome and adrenal suppression monitored for systemic corticosteroid have been reported in patients effects. receiving ritonavir and inhaled or intranasally administered Alternative corticosteroids which are fluticasone. The effects of high less dependent on CYP3A fluticasone systemic exposure on metabolism ritonavir plasma levels are e.g. beclomethasone should be unknown. considered, particularly for long term use. Other corticosteroids: interaction not studied. Plasma concentrations of these medicinal products may be increased when co-administered with boosted darunavir, resulting in reduced serum cortisol concentrations. Dexamethasone (systemic) Not studied. Dexamethasone may Systemic dexamethasone should be decrease plasma concentrations of used with caution when combined darunavir. with boosted darunavir. (CYP3A induction)

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) carvedilol (HOS-115322) risperidone (HOS-086280) amlodipine (HOS-086287) thioridazine (HOS-086281) perphenazine (HOS-116395) calcium (HOS-085615) betamethasone (HOS-090066) dexamethasone (HOS-084535) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) propionate (HOS-108915) ritonavir (HOS-084521) beclomethasone (HOS-086334) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)