Wechselwirkungen · Olumiant
Olumiant 2 mg/mL oral suspension · Abschnitt 4.5 · PDF-Seite 47
HOS-134836 · Präparat HOS-097616
Transporters In vitro, baricitinib is not an inhibitor of OAT1, OAT2, OAT3, organic cationic transporter (OCT) 2, OATP1B1, OATP1B3, BCRP, MATE1 and MATE2-K at clinically relevant concentrations. Baricitinib may be a clinically relevant inhibitor of OCT1, however there are currently no known selective OCT1 substrates for which clinically significant interactions might be predicted. In clinical pharmacology studies there were no clinically meaningful effects on exposure when baricitinib was coadministered with digoxin (Pgp substrate) or methotrexate (substrate of several transporters).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): digoxin (HOS-086172) methotrexate (HOS-087522)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-13T16:57:00Z · SHA-256 21fbeaddabb6b542aa078c68b96c452bd5c5e255d57f8087fb5e2094fcf4ef31 · Passage 0cbdef44212e481563b88d34a702099f5875b72c1ddea124af6cdc3de8a9fa14 · Zeichen 3022–3612 im Abschnitt