Wechselwirkungen · Rydapt
Rydapt 25 mg soft capsules · Abschnitt 4.5 · PDF-Seite 7
HOS-135074 · Präparat HOS-097652
Strong CYP3A4 inhibitors Strong CYP3A4 inhibitors may increase midostaurin blood concentrations. In a study with 36 healthy subjects, co-administration of the strong CYP3A4 inhibitor ketoconazole to steady state with a single dose of 50 mg midostaurin led to a significant increase in midostaurin exposure (1.8-fold Cmax increase and 10-fold AUCinf increase) and 3.5-fold increase in AUCinf of CGP62221, while the Cmax of the active metabolites (CGP62221 and CGP52421) decreased by half (see section 5.2). At steady state of midostaurin (50 mg twice daily for 21 days), with the strong CYP3A4 inhibitor itraconazole at steady state in a subset of patients (N=7), midostaurin steady-state exposure (Cmin) was increased by 2.09-fold. Cmin of CGP52421 was increased by 1.3-fold, whereas no significant effect in exposure of CGP62221 was observed (see section 4.4).
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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ketoconazole (HOS-084513) itraconazole (HOS-084516)
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Version 2026-01-14T02:00:00Z · SHA-256 8f1ec9efb6021159ac982022053e37b35f5bff1afb750b66862153d8db724917 · Passage e028c6bdfcf634d3375e59111a72deced6a3ed77dfb28cfa0911eabbaefe8b2e · Zeichen 1039–1900 im Abschnitt