Nebenwirkungen · Cabometyx
CABOMETYX 20 mg film-coated tablets CABOMETYX 40 mg film-coated tablets CABOMETYX 60 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 15–16
HOS-135849 · Präparat HOS-097776
15 In the HCC study (CELESTIAL), hepatic encephalopathy (hepatic encephalopathy, encephalopathy, hyperammonaemic encephalopathy) was reported in 5.6% of cabozantinib-treated patients (26/467); Grade 3-4 events in 2.8%, and one (0.2%) Grade 5 event. Median time to onset was 5.9 weeks. In the NET study (CABINET), hepatic encephalopathy was reported in 0.9% of cabozantinib-treated patients (2/227); There was one Grade 3 event (0.4%) for which median time to onset was 14.3 weeks. No cases of hepatic encephalopathy were reported in the RCC studies (METEOR, CABOSUN and CA2099ER) and in the DTC study (COSMIC-311).
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