Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Epclusa

Epclusa 200 mg/50 mg coated granules in sachet Epclusa 150 mg/37.5 mg coated granules in sachet · Abschnitt 4.5 · PDF-Seite 43

HOS-136195 · Präparat HOS-097846

Velpatasvir ↑ ↑ ↑ 1.6 2.4 4.0 (1.4, (2.2, (3.6, 1.7) 2.6) 4.5) Darunavir boosted with Darunavir ↔ ↔ ↔ No dose adjustment of Epclusa, ritonavir (800/ 100 mg once Ritonavir ↔ ↔ ↔ darunavir (ritonavir boosted) or daily) + emtricitabine/ Sofosbuvir ↓ ↓ emtricitabine/ tenofovir disoproxil tenofovir disoproxil 0.62 0.72 fumarate is required. fumarate (200/ 300 mg once (0.54, (0.66, daily)/ sofosbuvir/ 0.71) 0.80) velpatasvir (400/ 100 mg Velpatasvir ↓ ↔ ↔ once daily)c, d 0.76 (0.65, 0.89) Lopinavir boosted with Lopinavir ↔ ↔ ↔ No dose adjustment of Epclusa, ritonavir (4x200 mg/ 50 mg Ritonavir ↔ ↔ ↔ lopinavir (ritonavir boosted) or once daily) + emtricitabine/ Sofosbuvir ↓ ↓ emtricitabine/ tenofovir disoproxil tenofovir disoproxil 0.59 0.7 fumarate is required. fumarate (200/ 300 mg once (0.49 (0.6, daily)/ sofosbuvir/ 0.71) 0.8) velpatasvir (400/ 100 mg Velpatasvir ↓ ↔ ↑ once daily)c, d 0.70 1.6 (0.59, (1.4, 0.83) 1.9) HIV ANTIVIRAL AGENTS: INTEGRASE INHIBITORS Raltegravir (400 mg twice Raltegravir ↔ ↔ ↓ No dose adjustment of Epclusa, daily)g + emtricitabine/ 0.79 raltegravir or emtricitabine/ tenofovir disoproxil (0.42, tenofovir disoproxil fumarate is fumarate (200/ 300 mg once 1.5) required. daily)/ sofosbuvir/ Sofosbuvir ↔ ↔ velpatasvir (400/ 100 mg Velpatasvir ↔ ↔ ↔ once daily)c, d

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lopinavir (HOS-086269) tenofovir disoproxil (HOS-108843) fumarate (HOS-108845) darunavir (HOS-086181) tenofovir disoproxil fumarate (HOS-110471) raltegravir (HOS-086187) ritonavir (HOS-084521) emtricitabine (HOS-085840)