Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Emtricitabine/Tenofovir disoproxil Krka

Emtricitabine/Tenofovir disoproxil Krka 200 mg/245 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 20–21

HOS-136618 · Präparat HOS-097888

20 Very common: hypophosphataemia1 Common: hyperglycaemia, hypertriglyceridaemia Uncommon: hypokalaemia1 Rare: lactic acidosis Psychiatric disorders: Common: insomnia, abnormal dreams Nervous system disorders: Very common: headache dizziness Common: dizziness headache Gastrointestinal disorders: Very common: diarrhoea, nausea diarrhoea, vomiting, nausea Common: elevated amylase including elevated abdominal pain, abdominal pancreatic amylase, elevated serum distension, flatulence lipase, vomiting, abdominal pain, dyspepsia Uncommon: pancreatitis Hepatobiliary disorders: Common: elevated serum aspartate increased transaminases aminotransferase (AST) and/or elevated serum alanine aminotransferase (ALT), hyperbilirubinaemia Rare: hepatic steatosis, hepatitis Skin and subcutaneous tissue disorders: Very common: rash Common: vesiculobullous rash, pustular rash, maculopapular rash, rash, pruritus, urticaria, skin discolouration (increased pigmentation)2 Uncommon: angioedema3 Rare: angioedema Musculoskeletal and connective tissue disorders: Very common: elevated creatine kinase Common: bone mineral density decreased Uncommon: rhabdomyolysis1, muscular weakness1 Rare: osteomalacia (manifested as bone pain and infrequently contributing to fractures)1,3, myopathy1 Renal and urinary disorders: Uncommon: increased creatinine, proteinuria, proximal renal tubulopathy including Fanconi syndrome Rare: renal failure (acute and chronic), acute tubular necrosis, nephritis (including acute interstitial nephritis)3, nephrogenic diabetes insipidus General disorders and administration site conditions: Very common: asthenia Common: pain, asthenia

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