Wechselwirkungen · Verzenios
Verzenios 50 mg film-coated tablets Verzenios 100 mg film-coated tablets Verzenios 150 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-137580 · Präparat HOS-098067
Medicinal products that are substrates of transporters Abemaciclib and its major active metabolites inhibit the renal transporters organic cation transporter 2 (OCT2), multidrug and extrusion toxin protein (MATE1), and MATE2-K. In vivo interactions of abemaciclib with clinically relevant substrates of these transporters, such as dofetilide or creatinine, may occur (see section 4.8). In a clinical drug interaction study with metformin (substrate of OCT2, MATE1 and 2) co-administered with 400 mg abemaciclib, a small but not clinically relevant increase (37 %) in metformin plasma exposure was observed. This was found to be due to reduced renal secretion with unaffected glomerular filtration.
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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): dofetilide (HOS-085598) creatinine (HOS-086273) metformin (HOS-091032)
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