Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Symtuza

Symtuza 800 mg/150 mg/200 mg/10 mg film-coated tablets Symtuza 675 mg/150 mg/200 mg/10 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 11

HOS-138482 · Präparat HOS-098200

Clopidogrel Based on theoretical Co-administration of Symtuza considerations co-administration of with clopidogrel is not Symtuza with clopidogrel is recommended. Use of other expected to decrease clopidogrel antiplatelets not affected by CYP active metabolite plasma inhibition or induction (e.g. concentration, which may reduce prasugrel) is recommended (see the antiplatelet activity of section 4.3). clopidogrel. Warfarin Based on theoretical It is recommended that the considerations DRV/COBI may international normalised ratio alter warfarin plasma (INR) be monitored when concentrations. warfarin is co-administered with Symtuza. ANTICONVULSANTS Carbamazepine Based on theoretical Co-administration of Symtuza Phenobarbital considerations these and these anticonvulsants is Phenytoin anticonvulsants are expected to contraindicated (see section 4.3). decrease darunavir and/or cobicistat and/or tenofovir alafenamide plasma concentrations. (CYP3A and/or P-gp induction). Oxcarbazepine Co-administration of Symtuza with oxcarbazepine is not recommended. Alternative anticonvulsants should be considered. Clonazepam Based on theoretical considerations Clinical monitoring is Symtuza is expected to increase recommended when concentrations of clonazepam. co-administering Symtuza with (inhibition of CYP3A) clonazepam. ANTI-DEPRESSANTS Herbal supplements Based on theoretical considerations Co-administration of St. John’s Wort St. John’s Wort is expected to St. John’s Wort and Symtuza is decrease darunavir and/or contraindicated (see section 4.3). cobicistat and/or tenofovir alafenamide plasma concentrations. (CYP3A and/or P-gp induction)

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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tenofovir (HOS-088083) phenobarbital (HOS-085617) carbamazepine (HOS-085618) clonazepam (HOS-116372) clopidogrel (HOS-087927) prasugrel (HOS-112066) oxcarbazepine (HOS-110224) phenytoin (HOS-084531) warfarin (HOS-085950)