Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Symtuza

Symtuza 800 mg/150 mg/200 mg/10 mg film-coated tablets Symtuza 675 mg/150 mg/200 mg/10 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 12

HOS-138484 · Präparat HOS-098200

Based on theoretical considerations Amitriptyline DRV/COBI is expected to increase Desipramine these anti-depressant plasma Imipramine concentrations. Nortriptyline (CYP2D6 and/or CYP3A Trazodone inhibition) ANTI-DIABETICS Metformin Based on theoretical considerations Careful clinical monitoring and DRV/COBI is expected to increase dose adjustment of metformin is metformin plasma concentrations. recommended in patients who are (MATE1 inhibition) taking Symtuza. ANTIEMETICS Domperidone Not studied. Co-administration of domperidone with Symtuza is contraindicated. ANTIFUNGALS Clotrimazole Based on theoretical considerations Caution is warranted and clinical Fluconazole DRV/COBI is expected to increase monitoring is recommended. Itraconazole these antifungal plasma When co-administration is concentrations, and darunavir, required, the daily dose of Isavuconazole cobicistat and/or tenofovir itraconazole should not exceed Posaconazole alafenamide plasma concentrations 200 mg. may be increased by the antifungals. (CYP3A and/or P-gp inhibition)

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tenofovir (HOS-088083) isavuconazole (HOS-085186) nortriptyline (HOS-086245) amitriptyline (HOS-085911) desipramine (HOS-086249) imipramine (HOS-085907) clotrimazole (HOS-090574) domperidone (HOS-114656) itraconazole (HOS-084516) trazodone (HOS-086251) fluconazole (HOS-087945) posaconazole (HOS-085622) metformin (HOS-091032)