Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Symtuza

Symtuza 800 mg/150 mg/200 mg/10 mg film-coated tablets Symtuza 675 mg/150 mg/200 mg/10 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 14

HOS-138490 · Präparat HOS-098200

Lurasidone The combination of lurasidone, Pimozide pimozide, quetiapine or sertindole Quetiapine and Symtuza is contraindicated Sertindole (see section 4.3). β-BLOCKERS Carvedilol Based on theoretical considerations Clinical monitoring is Metoprolol DRV/COBI is expected to increase recommended when Timolol these beta-blocker plasma co-administering Symtuza with concentrations. beta-blockers and a lower dose of (CYP2D6 inhibition) the beta-blocker should be considered. CALCIUM CHANNEL BLOCKERS Amlodipine Based on theoretical considerations Clinical monitoring is Diltiazem DRV/COBI is expected to increase recommended when these Felodipine these calcium channel blocker medicinal products are Nicardipine plasma concentrations. co-administered with Symtuza. Nifedipine (CYP3A inhibition) Verapamil CORTICOSTEROIDS Corticosteroids primarily Based on theoretical considerations Concomitant use of Symtuza and metabolised by CYP3A DRV/COBI is expected to increase corticosteroids (all routes of (including betamethasone, these corticosteroid plasma administration) that are budesonide, fluticasone, concentrations. metabolised by CYP3A may mometasone, prednisone, (CYP3A inhibition) increase the risk for development triamcinolone) of systemic corticosteroid effects, including Cushing’s syndrome and adrenal suppression.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) quetiapine (HOS-086150) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) carvedilol (HOS-115322) amlodipine (HOS-086287) calcium (HOS-085615) betamethasone (HOS-090066) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)