Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Symtuza

Symtuza 800 mg/150 mg/200 mg/10 mg film-coated tablets Symtuza 675 mg/150 mg/200 mg/10 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 16–17

HOS-138497 · Präparat HOS-098200

16 OESTROGEN-BASED CONTRACEPTIVES Drospirenone Ethinylestradiol drospirenone AUC ↑ 58% Alternative or additional (3 mg/0.02 mg once daily) drospirenone Cmax ↑ 15% contraceptive measures are drospirenone Cmin ND recommended when oestrogen based contraceptives are Ethinylestradiol ethinylestradiol AUC  30% co-administered with Symtuza. ethinylestradiol Cmax  14% Patients using oestrogens as hormone replacement therapy ethinylestradiol Cmin ND should be clinically monitored for signs of oestrogen deficiency. Norethindrone When Symtuza is co-administered Based on theoretical considerations with a drospirenone-containing DRV/COBI may alter product, clinical monitoring is norethindrone plasma recommended due to the potential concentrations. for hyperkalaemia. OPIOID ANTAGONIST Naloxegol Not studied. Co-administration of Symtuza and naloxegol is contraindicated. PHOSPHODIESTERASE, TYPE 5 (PDE-5) INHIBITORS For the treatment of erectile Based on theoretical considerations Concomitant use of PDE-5 dysfunction DRV/COBI is expected to increase inhibitors for the treatment of Sildenafil these PDE-5 inhibitor plasma erectile dysfunction with Symtuza Tadalafil concentrations. should be done with caution. If Vardenafil (CYP3A inhibition) concomitant use of Symtuza with sildenafil, vardenafil or tadalafil is indicated, sildenafil at a single dose not exceeding 25 mg in 48 hours, vardenafil at a single dose not exceeding 2.5 mg in 72 hours or tadalafil at a single dose not exceeding 10 mg in 72 hours is recommended.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tadalafil (HOS-086316) drospirenone (HOS-116422) naloxegol (HOS-109428) norethindrone (HOS-088136) sildenafil (HOS-086162) vardenafil (HOS-086163)