Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Tacforius

Tacforius 0.5 mg prolonged-release hard capsules Tacforius 1 mg prolonged-release hard capsules Tacforius 3 mg prolonged-release hard capsules Tacforius 5 mg prolonged-release hard capsules · Abschnitt 4.5 · PDF-Seite 11

HOS-139155 · Präparat HOS-098290

Drug/Substance Class or Drug interaction effect Recommendations concerning Name co-administration Grapefruit or grapefruit juice May increase tacrolimus whole Avoid grapefruit or grapefruit blood trough concentrations and juice. increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) (see section 4.4). Ciclosporin May increase tacrolimus whole The simultaneous use of blood trough concentrations. In ciclosporin and tacrolimus addition, synergistic/additive should be avoided (see section nephrotoxic effects can occur. 4.4). Products known to have May enhance nephrotoxic or Concurrent use of tacrolimus nephrotoxic or neurotoxic neurotoxic effects of tacrolimus. with drugs known to have effects: nephrotoxic effects should be aminoglycosides, gyrase avoided. When co- inhibitors, vancomycin, administration cannot be sulfamethoxazole + avoided, monitor renal trimethoprim, NSAIDs, function and other side effects ganciclovir, aciclovir, and adjust tacrolimus dose if amphotericin B, ibuprofen, needed. cidofovir, foscarnet

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): foscarnet (HOS-110484) sulfamethoxazole (HOS-084533) ibuprofen (HOS-087884) amphotericin B (HOS-109312) trimethoprim (HOS-085184) cidofovir (HOS-110482) grapefruit juice (HOS-088787) vancomycin (HOS-110486) ganciclovir (HOS-085194)