Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Prevymis

PREVYMIS 20 mg granules in sachet PREVYMIS 120 mg granules in sachet · Abschnitt 4.5 · PDF-Seite 79

HOS-139952 · Präparat HOS-098408

When letermovir is co-administered with cyclosporine, the magnitude of the increase in concentrations of sirolimus may be greater than with letermovir alone. tacrolimus ↑ tacrolimus Frequent monitoring of tacrolimus whole (5 mg single dose)/ AUC 2.42 (2.04, 2.88) blood concentrations should be performed letermovir (480 mg Cmax 1.57 (1.32, 1.86) during treatment, when changing daily) (CYP3A inhibition) letermovir administration route, and at tacrolimus discontinuation of letermovir and the dose (5 mg single dose)/ ↔ letermovir of tacrolimus adjusted accordingly#. letermovir (80 mg AUC 1.02 (0.97, 1.07) twice daily) Cmax 0.92 (0.84, 1.00) Oral contraceptives ethinylestradiol (EE) ↔ EE No dose adjustment required. (0.03 mg)/ AUC 1.42 (1.32, 1.52) levonorgestrel Cmax 0.89 (0.83, 0.96) (LNG)‡ (0.15 mg) single ↔ LNG dose/ letermovir AUC 1.36 (1.30, 1.43) (480 mg daily) Cmax 0.95 (0.86, 1.04) Other systemically Risk of ↓ contraceptive Letermovir may reduce plasma acting oral steroids concentrations of other oral contraceptive contraceptive steroids thereby affecting their efficacy. steroids For adequate contraceptive effect to be ensured with an oral contraceptive, products containing EE and LNG should be chosen.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): levonorgestrel (HOS-089677) tacrolimus (HOS-085202) sirolimus (HOS-085172) cyclosporine (HOS-084512)