Wechselwirkungen · Epidyolex
Epidyolex 100 mg/ml oral solution · Abschnitt 4.5 · PDF-Seite 7
HOS-140602 · Präparat HOS-098554
The strong CYP3A4/2C19 inducing agent rifampicin (600 mg administered once daily) decreased plasma concentrations of cannabidiol and of 7-hydroxy-cannabidiol (7-OH-CBD; an active metabolite of cannabidiol) by approximately 30% and 60%, respectively. Other strong inducers of CYP3A4 and/or CYP2C19, such as carbamazepine, enzalutamide, mitotane, and St. John’s wort, when administered concomitantly with cannabidiol, may also cause a decrease in the plasma concentrations of cannabidiol and of 7-OH-CBD by a similar amount. These changes may result in a decrease in the effectiveness of cannabidiol. Dose adjustment may be necessary.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): carbamazepine (HOS-085618) mitotane (HOS-112479) enzalutamide (HOS-116829)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-08-20T11:14:00Z · SHA-256 ccb7fce36b37a5c512676c2475ea9ab250d2fd66d8e1f76a5048e693726825e9 · Passage 9b22d2b0dacd75b4c3551c30535a8b0679999ad73f68cbc53ad94c89d99f57af · Zeichen 28–660 im Abschnitt