Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Mayzent

Mayzent 0.25 mg film-coated tablets Mayzent 1 mg film-coated tablets Mayzent 2 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 12

HOS-140781 · Präparat HOS-098578

CYP2C9 and CYP3A4 inducers Siponimod may be combined with most types of CYP2C9 and CYP3A4 inducers. However, because of an expected reduction in siponimod exposure, the appropriateness and possible benefit of the treatment should be considered when siponimod is combined: - with dual strong CYP3A4/moderate CYP2C9 inducers (e.g. rifampicin, carbamazepine) in all patients, regardless of genotype. Co-administration of 2 mg siponimod and 600 mg rifampicin decreased siponimod AUCtau,ss and Cmax,ss by 57% and 45%, respectively, in CYP2C9*1*1 subjects. - with moderate CYP3A4 inducers (e.g. efavirenz, modafinil) for patients with a CYP2C9*1*3 or *2*3 genotype. The most pronounced reduction of siponimod exposure by 35% (AUCtau,ss) and 39% (Cmax,ss) is predicted after co-administration of 1 mg siponimod daily and 600 mg efavirenz daily in patients with CYP2C9*1*3 genotype compared to those with CYP2C9*1*1 genotype receiving their recommended dose of 2 mg siponimod without concomitant medication. No clinical data for siponimod combined with moderate CYP3A4 inducers are available.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): siponimod (HOS-140758) modafinil (HOS-090546) carbamazepine (HOS-085618) efavirenz (HOS-087947)