Nebenwirkungen · Imfinzi
IMFINZI 50 mg/ml concentrate for solution for infusion. · Abschnitt 4.8 · PDF-Seite 16
HOS-141801 · Präparat HOS-098696
IMFINZI in combination with tremelimumab 300 mg The safety of IMFINZI given in combination with a single dose of tremelimumab 300 mg is based on pooled data (HCC pool) in 462 HCC patients from the HIMALAYA Study and another study in HCC patients, Study 22. The most common (> 10%) adverse reactions were rash (32.5%), pruritus (25.5%), diarrhoea (25.3%), abdominal pain (19.7%), aspartate aminotransferase increased/alanine aminotransferase increased (18.0%), pyrexia (13.9%), hypothyroidism (13.0%), cough/productive cough (10.8%), oedema peripheral (10.4%) and lipase increased (10.0%) (see Table 4). The most common severe adverse reactions (NCI CTCAE Grade ≥ 3) were aspartate aminotransferase increased/alanine aminotransferase increased (8.9%), lipase increased (7.1%), amylase increased (4.3%) and diarrhoea (3.9%).
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Version 2026-05-18T16:10:00Z · SHA-256 2aea150cfee5fbe605596424a5c30efdb4cdb269005b61f75a72ebb78beb905f · Passage 9fe499708ced7632e8d190a562c31854204240e164d047c586a76502eb0fdbc2 · Zeichen 4927–5749 im Abschnitt