Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Dovato

Dovato 50 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10–11

HOS-142841 · Präparat HOS-098886

10 Cytotoxics Cladribine/Lamivudine Interaction not studied. Concomitant use of Dovato with cladribine is not recommended (see In vitro lamivudine section 4.4). inhibits the intracellular phosphorylation of cladribine leading to a potential risk of cladribine loss of efficacy in case of combination in the clinical setting. Some clinical findings also support a possible interaction between lamivudine and cladribine. Miscellaneous Sorbitol Sorbitol solution (3.2 g, 10.2 g, Single dose lamivudine When possible, avoid chronic 13.4 g)/Lamivudine oral solution 300 mg. coadministration of Dovato with medicinal products containing sorbitol Lamivudine: or other osmotic acting poly-alcohols or AUC  14%; 32%; 36% monosaccharide alcohols (eg: xylitol, mannitol, lactitol, maltitol). Consider Cmax  28%; 52%, 55%. more frequent monitoring of HIV-1 viral load when chronic coadministration cannot be avoided. Potassium channel blockers Fampridine (also known as Fampridine  Co-administration of dolutegravir has dalfampridine)/Dolutegravir the potential to cause seizures due to increased fampridine plasma concentration via inhibition of OCT2 transporter; co-administration has not been studied. Fampridine co- administration with Dovato is contraindicated (see section 4.3). Antacids and supplements Magnesium/ Dolutegravir  Magnesium/ aluminium-containing aluminium-containing AUC  74% antacids should be taken well separated antacids/Dolutegravir Cmax  72% in time from the administration of Dovato (minimum 2 hours after or (Complex binding to 6 hours before). polyvalent ions) Calcium Dolutegravir  - When taken with food, Dovato and supplements/Dolutegravir AUC  39% supplements or multivitamins containing (fasted intake) Cmax  37% calcium, iron or magnesium can be taken C24  39% at the same time. (Complex binding to - If Dovato is taken in a fasted state, polyvalent ions) such supplements should be taken a Iron supplements/Dolutegravir Dolutegravir  minimum 2 hours after or 6 hours before (fasted intake) AUC  54% the intake of Dovato. Cmax  57% C24  56% The stated reductions in dolutegravir (Complex binding to exposure were observed with the intake polyvalent ions) of dolutegravir and these supplements

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): maltitol (HOS-085849) calcium (HOS-085615) iron (HOS-085656) xylitol (HOS-085846) dalfampridine (HOS-124191) mannitol (HOS-085847) lactitol (HOS-085848) potassium (HOS-086929) magnesium (HOS-085165) sorbitol (HOS-085845) cladribine (HOS-085842)