Nebenwirkungen · Nilemdo
Nilemdo 180 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 8
HOS-143239 · Präparat HOS-098954
Effects on serum creatinine and blood urea nitrogen Bempedoic acid has been shown to increase serum creatinine and blood urea nitrogen (BUN). In the phase 3 primary hyperlipidemia studies, a mean increase of 4.4 micromole/L (0.05 mg/dL) in serum creatinine and a mean increase of 0.61 mmol/L (1.7 mg/dL) in BUN compared to baseline was observed with bempedoic acid at week 12. The elevations in serum creatinine and BUN usually occurred within the first 4 weeks of treatment, remained stable, and returned to baseline following discontinuation of treatment. Similar mean increases in serum creatinine (5.8 micromole/L (0.066 mg/dL)) and BUN (0.82 mmol/L (2.3 mg/dL)) were observed with bempedoic acid in the CLEAR Outcomes study.
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Version 2026-02-27T17:50:00Z · SHA-256 e22c45bda49313040ac4a284f068b61ba66ef21d794753c9c1627e320bff57f6 · Passage 435f4baaf6d84e7e17dbd506a0d648208d8c963b88c25c8bb9452b14007b78e9 · Zeichen 5654–6383 im Abschnitt