Nebenwirkungen · Carvykti
CARVYKTI 3.2 × 106 – 1 × 108 cells dispersion for infusion · Abschnitt 4.8 · PDF-Seite 18
HOS-144285 · Präparat HOS-099146
Peripheral neuropathy In the pooled studies (N=396), 28 patients developed peripheral neuropathy, presenting as sensory, motor, or sensorimotor neuropathies. Median time of onset of symptoms was 58 days (range: 1 to 914 days), median duration of peripheral neuropathies was 142 days (range: 1 to 1062 days) including those with ongoing neuropathy. Of these 28 patients, 5 experienced Grade 3 or Grade 4 peripheral neuropathy (which resolved in 1 patient with no treatment reported, and was ongoing in the other 4 patients, including one patient who improved after treatment with dexamethasone). Of the remaining 23 with ≤ Grade 2 peripheral neuropathy, peripheral neuropathy resolved with no treatment reported in 7 patients and following treatment with duloxetine in 3 patients, and was ongoing in the other 9 patients.
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