Wechselwirkungen · Ozawade
Ozawade 4.5 mg film-coated tablets Ozawade 18 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 5
HOS-144425 · Präparat HOS-099178
- Enzyme inducers CYP3A inducers will most likely have an effect on the pharmacokinetics of pitolisant in CYP2D6 poor metabolizers and CYP2D6 ultra-rapid metabolizers and their effect in these populations is currently unknown. A clinical monitoring should be made when both active substances are combined and, eventually a dosage adjustment during the combination and one week after the inducer treatment. Co-administration of pitolisant with rifampicin in multiple doses significantly decreases pitolisant mean Cmax and AUC ratio about 0.6-fold and 0.5-fold, respectively. Therefore, co-administration of pitolisant with potent CYP3A4 inducers (e.g. rifampicin, phenobarbital, carbamazepine, phenytoin) should be done with caution. With St John’s Wort (Hypericum perforatum), due to its strong CYP3A4 inducing effect, caution should be exercised when taken concurrently with pitolisant.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) carbamazepine (HOS-085618) phenytoin (HOS-084531)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-08-06T11:36:00Z · SHA-256 6132349ff4302f19688e606b853696608a2e68d699ec2c7f66e494671825abac · Passage eec33ca6c2cbd3d2ac36f0ffa1b1a01067a486a7f7693da0855c353396f883e3 · Zeichen 2441–3333 im Abschnitt