Wechselwirkungen · Kerendia
Kerendia 10 mg film-coated tablets Kerendia 20 mg film-coated tablets Kerendia 40 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10
HOS-145307 · Präparat HOS-099328
Effect of 40 mg finerenone on CYP3A4 and CYP2C8 substrates At 40 mg once daily, finerenone is a weak inhibitor of the CYP3A4 enzyme in vivo. Co-administration of multiple doses of 40 mg finerenone with the CYP3A4 probe substrate midazolam resulted in a 1.31-fold increase in mean midazolam AUC with no effect on Cₘₐₓ. The potentially increased exposure of sensitive CYP3A4 substrates with a narrow therapeutic window needs to be considered when used concomitantly with finerenone 40 mg once daily. A multiple-dose regimen of 20 mg finerenone given once daily for 10 days had no relevant effect on the AUC of the CYP3A4 probe substrate midazolam. Therefore, a clinically relevant inhibition or induction of CYP3A4 by finerenone can be excluded at this dose level.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): midazolam (HOS-086167)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-05-07T09:57:00Z · SHA-256 98ba233d390b44b94791f7f65cd1eff51a109db99630ace3897a132ef234b558 · Passage be354314d38b03ea5bcf99fbe532879ceec818dbfdc4e8d40225f422840884c2 · Zeichen 3198–3960 im Abschnitt