Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Wegovy

Wegovy 0.25 mg solution for injection in pre-filled pen Wegovy 0.5 mg solution for injection in pre-filled pen Wegovy 1 mg solution for injection in pre-filled pen Wegovy 1.7 mg solution for injection in pre-filled pen Wegovy 2.4 mg solution for injection in pre-filled pen Wegovy 7.2 mg solution for injection in pre-filled pen Wegovy 0.25 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.5 mg FlexTouch solution for injection in pre-filled pen Wegovy 1 mg FlexTouch solution for injection in pre-filled pen Wegovy 1.7 mg FlexTouch solution for injection in pre-filled pen Wegovy 2.4 mg FlexTouch solution for injection in pre-filled pen Wegovy 0.25 mg solution for injection in pre-filled syringe Wegovy 0.5 mg solution for injection in pre-filled syringe Wegovy 1 mg solution for injection in pre-filled syringe Wegovy 1.7 mg solution for injection in pre-filled syringe Wegovy 2.4 mg solution for injection in pre-filled syringe · Abschnitt 4.8 · PDF-Seite 12

HOS-147322 · Präparat HOS-099634

Immunogenicity Consistent with the potentially immunogenic properties of medicinal products containing proteins or peptides, patients may develop antibodies following treatment with semaglutide. The proportion of patients testing positive for anti-semaglutide antibodies at any time post-baseline was 2.9 – 10.9% for semaglutide 2.4 mg and 15.3% for semaglutide 7.2 mg. No patients had anti-semaglutide neutralising antibodies or anti-semaglutide antibodies with endogenous GLP-1 neutralising effect. During treatment, high semaglutide concentrations might have lowered the sensitivity of the assays, hence the risk of false negatives cannot be excluded. However, in subjects testing positive for antibodies during and after treatment, the presence of antibodies was transient and with no apparent impact on efficacy and safety.

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