Nebenwirkungen · Pyrukynd
Pyrukynd 5 mg film-coated tablets Pyrukynd 20 mg film-coated tablets Pyrukynd 50 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 8
HOS-147906 · Präparat HOS-099782
In a Phase 2 study, 2 of 52 patients (3.8%) experienced haemolysis upon sudden withdrawal of Pyrukynd, including 1 serious adverse event of acute haemolysis. In both patients who received an initial Pyrukynd dose of 300 mg twice daily, a rapid and large Hb increase was observed during the first 3 weeks of treatment. This was followed by a sudden discontinuation of Pyrukynd without taper, which resulted in acute haemolysis with anaemia. Patients who missed a few doses of Pyrukynd later in their treatment course, or for whom the dose was tapered, did not experience events of acute haemolysis.
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