Nebenwirkungen · Pyrukynd
Pyrukynd 5 mg film-coated tablets Pyrukynd 20 mg film-coated tablets Pyrukynd 50 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 8
HOS-147907 · Präparat HOS-099782
Changes in sex hormone levels Mitapivat is a weak aromatase inhibitor in vitro. In ACTIVATE, 1 of 16 (6.3%) males experienced increases in testosterone to above normal levels and 2 of 16 (12.5%) and 9 of 16 (56.3%) males experienced decreases in oestradiol and oestrone below the lower limit of normal, respectively. In ACTIVATE-T, 1 of 7 males (14.3%) experienced oestrone decrease below the lower limit of normal. These changes in hormone levels were maintained throughout the study period. In patients who discontinued Pyrukynd at the end of the core period, the hormone changes were reversible. Sex hormone analysis in female patients was limited due to physiological variations in hormone levels expected throughout the normal menstrual cycle and the various types of hormonal contraceptives used by patients.
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Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-19T11:25:00Z · SHA-256 03d501776d0624826818135ad3ead3dbd02ded30f25a5a3920a5a762850351f5 · Passage 9e50a36e8156bbf669f209a669fb529d4424e349ebc2d16b05fe2115ff2b599c · Zeichen 2595–3409 im Abschnitt