Nebenwirkungen · Columvi
Columvi 2.5 mg concentrate for solution for infusion Columvi 10 mg concentrate for solution for infusion · Abschnitt 4.8 · PDF-Seite 20
HOS-149219 · Präparat HOS-100012
Grade 2 CRS occurred in 12.4% of patients following the first Columvi dose (2.5 mg) with median time to onset of 9.7 hours (range: 5.2 to 19.1 hours) and median duration of 50.4 hours (range: 6.5 to 316.7 hours). Following Columvi 10 mg dose at Cycle 1 Day 15, the incidence of Grade 2 CRS decreased to 5.2% of patients with median time to onset of 26.2 hours (range: 6.7 to 144.2 hours) and median duration of 30.9 hours (range: 3.7 to 227.2 hours). Grade 2 CRS following Columvi 30 mg dose at Cycle 2 Day 1 occurred in one patient (0.8%) with time to onset of 15.0 hours and duration of 44.8 hours. No Grade 2 CRS was reported beyond Cycle 2.
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Version 2026-10-20T13:00:00Z · SHA-256 2c5f4e2a70d7830059221b97eb832e6bb8ef846ec2df0243e5154b9f1ae1a38f · Passage 93759f36a894c3a53662d07ee1193f2f69df5e506abc21893ec05052fbccc897 · Zeichen 17861–18513 im Abschnitt