Nebenwirkungen · Degevma
Degevma 120 mg solution for injection · Abschnitt 4.8 · PDF-Seite 8
HOS-152307 · Präparat HOS-100725
In the primary treatment phases of three phase III active-controlled clinical trials in patients with advanced malignancies involving bone, ONJ was confirmed in 1.8% of patients treated with denosumab (median exposure of 12.0 months; range: 0.1 – 40.5) and 1.3% of patients treated with zoledronic acid. Clinical characteristics of these cases were similar between treatment groups. Among patients with confirmed ONJ, most (81% in both treatment groups) had a history of tooth extraction, poor oral hygiene, and/or use of a dental appliance. Most patients were receiving or had received chemotherapy.
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Version 2026-09-24T11:32:00Z · SHA-256 42d5e2a42bc26ec6cfe17bc16a0b6c7aefac65193465706eb459c472cc75aee0 · Passage 5cdde72542b155fad05ac817b75f81269db010d62706a02c6fa3641fd2b907ba · Zeichen 6750–7350 im Abschnitt