Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Rasilez

Rasilez 150 mg film-coated tablets Rasilez 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 6–7

HOS-208754 · Präparat HOS-154177

6 The available clinical data did not indicate that higher doses of torasemide were used after co-administration with aliskiren. Torasemide renal excretion is known to be mediated by organic anion transporters (OATs). Aliskiren is minimally excreted via the renal route, and only 0.6% of the aliskiren dose is recovered in urine following oral administration (see section 5.2). However, since aliskiren has been shown to be a substrate for the organic anion-transporting polypeptide 1A2 (OATP1A2) (see section “Organic anion transporting polypeptide (OATP” below) inhibitors), there is a potential for aliskiren to reduce plasma torasemide exposure by an interference with the absorption process.

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