Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Modigraf

Modigraf 0.2 mg granules for oral suspension Modigraf 1 mg granules for oral suspension · Abschnitt 4.5 · PDF-Seite 12–13

HOS-209770 · Präparat HOS-154375

12 Drug/Substance Class or Drug interaction effect Recommendations concerning co- Name administration dose may need to be adjusted gradually. Monitor graft function closely. Moderate CYP3A4 inducers: May decrease tacrolimus Monitor tacrolimus whole blood metamizole, phenobarbital, whole blood trough trough concentrations and isoniazid rifabutin, efavirenz, concentrations and increase increase tacrolimus dose if needed etravirine, nevirapine; weak the risk of rejection [see [see section 4.2]. CYP3A4 inducers: section 4.4]. Monitor graft function closely. flucloxacillin Caspofungin May decrease tacrolimus Monitor tacrolimus whole blood whole blood trough trough concentrations and concentrations and increase increase tacrolimus dose if needed the risk of rejection. [see section 4.2]. Monitor graft Mechanism of interaction has function closely. not been confirmed. Cannabidiol (P-gp inhibitor) There have been reports of Tacrolimus and cannabidiol increased tacrolimus blood should be co-administered with levels during concomitant caution, closely monitoring for use of tacrolimus with side effects. Monitor tacrolimus cannabidiol. This may be due whole blood trough to inhibition of intestinal P- concentrations and adjust the glycoprotein, leading to tacrolimus dose if needed [see increased bioavailability of sections 4.2 and 4.4]. tacrolimus. Products known to have high Tacrolimus is extensively Monitor tacrolimus whole blood affinity for plasma proteins, bound to plasma proteins. trough concentrations and adjust e.g.: NSAIDs, oral Possible interactions with tacrolimus dose if needed [see anticoagulants, oral other active substances section 4.2]. antidiabetics known to have high affinity for plasma proteins should be considered. Prokinetic agents: May increase tacrolimus Monitor tacrolimus whole blood metoclopramide, cimetidine whole blood trough trough concentrations and reduce and magnesium-aluminium- concentrations and increase tacrolimus dose if needed [see hydroxide the risk of serious adverse section 4.2]. reactions (e.g., neurotoxicity, Monitor closely for renal QT prolongation). function, for QT prolongation with ECG, and for other side effects. Maintenance doses of May decrease tacrolimus Monitor tacrolimus whole blood corticosteroids whole blood trough trough concentrations and concentrations and increase increase tacrolimus dose if needed the risk of rejection [see [see section 4.2]. section 4.4]. Monitor graft function closely. High dose prednisolone or May have impact on Monitor tacrolimus whole blood methylprednisolone tacrolimus blood levels trough concentrations and adjust (increase or decrease) when tacrolimus dose if needed. administered for the treatment of acute rejection.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): prednisolone (HOS-086337) caspofungin (HOS-109306) phenobarbital (HOS-085617) cimetidine (HOS-085835) rifabutin (HOS-086262) methylprednisolone (HOS-088374) metoclopramide (HOS-090626) etravirine (HOS-088088) cannabidiol (HOS-090609) efavirenz (HOS-087947) nevirapine (HOS-088064) isoniazid (HOS-088590)