Wechselwirkungen · Silodyx
Silodyx 4 mg hard capsules Silodyx 8 mg hard capsules · Abschnitt 4.5 · PDF-Seite 4
HOS-212824 · Präparat HOS-154982
PDE-5 inhibitors Minimal pharmacodynamic interactions have been observed between silodosin and maximum doses of sildenafil or tadalafil. In a placebo-controlled study in 24 subjects 45-78 years of age receiving silodosin, the co-administration of sildenafil 100 mg or tadalafil 20 mg induced no clinically meaningful mean decreases in systolic or diastolic blood pressure, as assessed by orthostatic tests (standing versus supine). In the subjects over 65 years, the mean decreases at the various time points were between 5 and 15 mmHg (systolic) and 0 and 10 mmHg (diastolic). Positive orthostatic tests were only slightly more common during co-administration; however, no symptomatic orthostasis or dizziness occurred. Patients taking PDE-5 inhibitors concomitantly with silodosin should be monitored for possible adverse reactions.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tadalafil (HOS-086316) sildenafil (HOS-086162)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-03-14T02:00:00Z · SHA-256 3160563a58a5c6e4d0b810ca0084cd37d41fc475981c0af61af721cac8f0e9d2 · Passage a393285d53b7466a2e9a8212524d9ecde4c450c48c262e88d34a71813ecb252e · Zeichen 1307–2141 im Abschnitt