Wechselwirkungen · Ristaben
Ristaben 25 mg film-coated tablets Ristaben 50 mg film-coated tablets Ristaben 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 5
HOS-213099 · Präparat HOS-155036
Ciclosporin: A study was conducted to assess the effect of ciclosporin, a potent inhibitor of p-glycoprotein, on the pharmacokinetics of sitagliptin. Co-administration of a single 100 mg oral dose of sitagliptin and a single 600 mg oral dose of ciclosporin increased the AUC and Cmax of sitagliptin by approximately 29 % and 68 %, respectively. These changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful. The renal clearance of sitagliptin was not meaningfully altered. Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors.
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