Wechselwirkungen · Ristfor
Ristfor 50 mg/850 mg film-coated tablets Ristfor 50 mg/1 000 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7
HOS-213137 · Präparat HOS-155044
Ciclosporin: A study was conducted to assess the effect of ciclosporin, a potent inhibitor of p-glycoprotein, on the pharmacokinetics of sitagliptin. Co-administration of a single 100 mg oral dose of sitagliptin and a single 600 mg oral dose of ciclosporin increased the AUC and Cmax of sitagliptin by approximately 29 % and 68 %, respectively. These changes in sitagliptin pharmacokinetics were not considered to be clinically meaningful. The renal clearance of sitagliptin was not meaningfully altered. Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors.
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Version 2025-11-17T16:59:00Z · SHA-256 b5a5e03c53fc129476a3d12e1af9319ad9c05981058770a65f90dce0b54d48da · Passage ea5930922accb6e665bd5dfce759b3989904fccb7dbe59f6a4314d214f67fef9 · Zeichen 4000–4599 im Abschnitt