Wechselwirkungen · Leflunomide ratiopharm
Leflunomide ratiopharm 10 mg film-coated tablets Leflunomide ratiopharm 20 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-213328 · Präparat HOS-155090
In vitro inhibition studies in human liver microsomes suggest that cytochrome P450 (CYP) 1A2, 2C19 and 3A4 are involved in leflunomide metabolism. An in vivo interaction study with leflunomide and cimetidine (non-specific weak cytochrome P450 (CYP) inhibitor) has demonstrated a lack of a significant impact on A771726 exposure. Following concomitant administration of a single dose of leflunomide to subjects receiving multiple doses of rifampicin (non-specific cytochrome P450 inducer) A771726 peak levels were increased by approximately 40%, whereas the AUC was not significantly changed. The mechanism of this effect is unclear.
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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cimetidine (HOS-085835)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-07-30T13:11:00Z · SHA-256 50316a891b82d00ee9a94d110a4117387e85a2bc5abc6b68dd9316418b3d816b · Passage 2d529ec81a6782a7490421cd26b2725b8483b281ec0bc06c692365321eeded38 · Zeichen 2694–3326 im Abschnitt