Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Eviplera

Eviplera 200 mg/25 mg/245 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 17

HOS-214411 · Präparat HOS-155326

Alternatives should be considered, particularly for long-term use. PROTON PUMP INHIBITORS Omeprazole/Emtricitabine Interaction not studied. Eviplera must not be used in Omeprazole (20 mg once daily)/ Omeprazole: combination with proton pump Rilpivirine1 AUC: ↓ 14% inhibitors as co-administration is Cmin: N/A likely to cause significant Cmax: ↓ 14% decreases in rilpivirine plasma concentrations (reduced Rilpivirine: absorption, increase in gastric pH). Lansoprazole2 AUC: ↓ 40% This may result in loss of Rabeprazole2 Cmin: ↓ 33% therapeutic effect of Eviplera (see Pantoprazole2 Cmax: ↓ 40% section 4.3). Esomeprazole2 Omeprazole/Tenofovir disoproxil Interaction not studied. H2-RECEPTOR ANTAGONISTS Famotidine/Emtricitabine Interaction not studied. The combination of Eviplera and Famotidine (40 mg single dose Rilpivirine: H2-receptor antagonists should be taken 12 hours before rilpivirine)/ AUC: ↓ 9% used with particular caution as Rilpivirine1 Cmin: N/A co-administration may cause Cmax: ↔ significant decreases in rilpivirine Cimetidine2 plasma concentrations (reduced Nizatidine2 absorption, increase in gastric pH). Ranitidine2 Only H2-receptor antagonists that Famotidine (40 mg single dose Rilpivirine: can be dosed once daily should be taken 2 hours before rilpivirine)/ AUC: ↓ 76% used. A strict dosing schedule Rilpivirine1 Cmin: N/A with intake of the H2-receptor Cmax: ↓ 85% antagonists at least 12 hours before Famotidine (40 mg single dose Rilpivirine: or at least 4 hours after Eviplera taken 4 hours after rilpivirine)/ AUC: ↑ 13% should be used. Rilpivirine1 Cmin: N/A Cmax: ↑ 21% Famotidine/Tenofovir disoproxil Interaction not studied. ANTACIDS Antacids (e.g. aluminium or Interaction not studied with any of The combination of Eviplera and magnesium hydroxide, calcium the components of Eviplera. antacids should be used with carbonate) caution as co-administration may cause significant decreases in rilpivirine plasma concentrations (reduced absorption, gastric pH increase). Antacids should only be administered either at least 2 hours before or at least 4 hours after Eviplera.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): famotidine (HOS-112087) magnesium hydroxide (HOS-088789) calcium (HOS-085615) omeprazole (HOS-085912)