Wechselwirkungen · Zelboraf
Zelboraf 240 mg film-coated tablets. · Abschnitt 4.5 · PDF-Seite 9
HOS-215564 · Präparat HOS-155464
Effects of concomitant medicines on vemurafenib In vitro studies suggest that CYP3A4 metabolism and glucuronidation are responsible for the metabolism of vemurafenib. Biliary excretion appears to be another important elimination pathway. In vitro studies have demonstrated that vemurafenib is a substrate of the efflux transporters P-gp and BCRP. It is currently unknown whether vemurafenib is a substrate also to other transport proteins. Concomitant administration of strong CYP3A4 inhibitors or inducers or inhibitors/inducer of transport protein activity may alter vemurafenib concentrations.
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Version 2025-06-19T10:15:00Z · SHA-256 2d456fa760308f0a3cd38ceefcce188400597f529dcb630f5163ed6664af53db · Passage 8a276d3dde486ad205664969b0b49615598ecdb86e92fb2b0933a373e2b2ebf8 · Zeichen 4793–5389 im Abschnitt