Nebenwirkungen · Holoclar
Holoclar 79,000 - 316,000 cells/cm2 living tissue equivalent · Abschnitt 4.8 · PDF-Seite 5–6
HOS-215679 · Präparat HOS-155496
5 Summary of the safety profile The most serious adverse reactions are corneal perforation and ulcerative keratitis, which may occur within the 3 months from Holoclar implantation and are related to the poor corneal stem cell engraftment, and syncope vasovagal occurring in the first day after surgery due to eye pain. The most common adverse reactions are eye disorders. The most frequently occurring reactions related to the surgical procedure were eye pain (4.0 %), corneal epithelium defect (3.4 %) and conjunctival haemorrhage (2.2 %), the latter appearing mostly during the first day after surgery and in most cases to be mild in intensity and disappearing within a few days without treatment.
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Version 2025-07-08T12:00:00Z · SHA-256 6a5557c894018fb1f4633931cd3d6e20d528eee4a07ae5fbfe29b6833aa24a79 · Passage dfa35edd9de431875f15b53d5cb9df4c845a4ad30c0cb2ed383832b8c2833040 · Zeichen 0–700 im Abschnitt