Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Lopinavir/Ritonavir Viatris (previously Ritonavir Mylan)

Lopinavir/Ritonavir Viatris 100 mg/25 mg film-coated tablets Lopinavir/Ritonavir Viatris 200 mg/50 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 12–13

HOS-222967 · Präparat HOS-217110

12 Co-administered drug by Effects on drug levels Clinical recommendation therapeutic area Geometric Mean Change (%) in concerning co-administration with AUC, Cmax , Cmin Lopinavir/Ritonavir Viatris Mechanism of interaction Clarithromycin Clarithromycin: For patients with renal impairment Moderate increases in clarithromycin (CrCL < 30 ml/min) dose reduction of AUC are expected due to CYP3A clarithromycin should be considered inhibition by lopinavir/ritonavir. (see section 4.4). Caution should be exercised in administering clarithromycin with Lopinavir/Ritonavir Viatris to patients with impaired hepatic or renal function. Anticancer agents and kinase inhibitors Abemaciclib Serum concentrations may be Co administration of abemaciclib and increased due to CYP3A inhibition Lopinavir/Ritonavir Viatris should be by ritonavir. avoided. If this co administration is judged unavoidable, refer to the abemaciclib SmPC for dosage adjustment recommendations. Monitor for ADRs related to abemaciclib. Apalutamide Apalutamide is a moderate to strong Decreased exposure of CYP3A4 inducer and this may lead Lopinavir/Ritonavir Viatris may result to a decreased exposure of in potential loss of virological lopinavir/ritonavir. response. In addition, co-administration of Serum concentrations of apalutamide apalutamide and Lopinavir/Ritonavir may be increased due to CYP3A Viatris may lead to serious adverse inhibition by lopinavir/ritonavir. events including seizure due to higher apalutamide levels. Concomitant use of Lopinavir/Ritonavir Viatris with apalutamide is not recommended. Afatinib Afatinib: Caution should be exercised in AUC: ↑ administering afatinib with (Ritonavir 200 mg twice Cmax : ↑ Lopinavir/Ritonavir Viatris. Refer to daily) the afatinib SmPC for dosage The extent of increase depends on the adjustment recommendations. timing of ritonavir administration. Monitor for ADRs related to afatinib

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): abemaciclib (HOS-086209) apalutamide (HOS-086212) lead (HOS-085592) afatinib (HOS-086207) clarithromycin (HOS-084517)