Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Atazanavir Viatris (previously Atazanavir Mylan)

Atazanavir Viatris 150 mg hard capsules Atazanavir Viatris 200 mg hard capsules Atazanavir Viatris 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 20–21

HOS-223205 · Präparat HOS-217134

20 Medicinal products by Interaction Recommendations therapeutic area concerning co- administration atazanavir (with or without ritonavir) is contraindicated due to the potential for loss of virologic response, development of resistance, increase in encorafenib plasma concentration and subsequent risk of serious adverse events such as QT interval prolongation (see section 4.3). Ivosidenib The mechanism of interaction is CYP3A4 Co-administration of inhibition by atazanavir and/or ritonavir. ivosidenib with atazanavir (with or without ritonavir) is contraindicated due to potential for loss of virologic response, development of resistance, increase in ivosidenib plasma concentration and subsequent risk of serious adverse events such as QT interval prolongation (see section 4.3). Irinotecan Atazanavir inhibits UGT and may interfere If atazanavir is with the metabolism of irinotecan, resulting in co-administered with increased irinotecan toxicities. irinotecan, patients should be closely monitored for adverse events related to irinotecan. Immunosuppressants Cyclosporin Concentrations of these immunosuppressants More frequent Tacrolimus may be increased when co-administered with therapeutic Sirolimus atazanavir due to CYP3A4 inhibition. concentration monitoring of these medicinal products is recommended until plasma levels have been stabilised. CARDIOVASCULAR AGENTS Antiarrhythmics Amiodarone, Systemic lidocaine, Concentrations of these antiarrhythmics may Caution is warranted Quinidine be increased when co-administered with and therapeutic atazanavir. The mechanism of amiodarone or concentration

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lidocaine (HOS-108866) quinidine (HOS-085593) encorafenib (HOS-086222) tacrolimus (HOS-085202) ivosidenib (HOS-112046) sirolimus (HOS-085172) ritonavir (HOS-084521) amiodarone (HOS-085596) irinotecan (HOS-112102)