Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Darunavir Krka

Darunavir Krka 400 mg film-coated tablets Darunavir Krka 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 17–18

HOS-225722 · Präparat HOS-217490

17  associated with these agents. Caution should be exercised when combining one of these antineoplastic agents with boosted darunavir. Everolimus Irinotecan Concomitant use of everolimus or irinotecan and boosted darunavir is not recommended. ANTIPSYCHOTICS/NEUROLEPTICS Quetiapine Not studied. Boosted darunavir is expected Concomitant administration of to increase these antipsychotic plasma boosted darunavir and quetiapine is concentrations. contraindicated as it may increase (CYP3A inhibition) quetiapine-related toxicity. Increased concentrations of quetiapine may lead to coma (see section 4.3). Perphenazine Not studied. Boosted darunavir is expected A dose decrease may be needed for Risperidone to increase these antipsychotic plasma these drugs when co-administered Thioridazine concentrations. with boosted darunavir. (CYP3A, CYP2D6 and/or P-gp inhibition) Lurasidone Concomitant administration of Pimozide boosted darunavir and lurasidone, Sertindole pimozide or sertindole is contraindicated (see section 4.3). β-BLOCKERS Carvedilol Not studied. Boosted darunavir is expected Clinical monitoring is recommended Metoprolol to increase these β-blocker plasma when co-administering boosted Timolol concentrations. darunavir with β-blockers. A lower (CYP2D6 inhibition) dose of the β-blocker should be considered. CALCIUM CHANNEL BLOCKERS Amlodipine Not studied. Boosted darunavir can be Clinical monitoring of therapeutic Diltiazem expected to increase the plasma and adverse reactions is Felodipine concentrations of calcium channel recommended when these medicines Nicardipine blockers. are concomitantly administered with Nifedipine (CYP3A and/or CYP2D6 inhibition) boosted darunavir. Verapamil CORTICOSTEROIDS Corticosteroids primarily Fluticasone: in a clinical study where Concomitant use of boosted metabolised by CYP3A ritonavir 100 mg capsules twice daily were darunavir and corticosteroids (all (including betamethasone, co-administered with 50 μg intranasal routes of administration) that are budesonide, fluticasone, fluticasone propionate (4 times daily) for metabolised by CYP3A may increase mometasone, prednisone, 7 days in healthy subjects, fluticasone the risk of development of systemic triamcinolone) propionate plasma concentrations corticosteroid effects, including increased significantly, whereas the Cushing's syndrome and adrenal intrinsic cortisol levels decreased by suppression. approximately 86% (90% CI 82-89%). Greater effects may be expected when Co-administration with CYP3A- fluticasone is inhaled. Systemic metabolised corticosteroids is not corticosteroid effects including Cushing's recommended unless the potential syndrome and adrenal suppression have benefit to the patient outweighs the been reported in patients receiving risk, in which case patients should be ritonavir and inhaled or intranasally monitored for systemic corticosteroid administered fluticasone. The effects of effects. high fluticasone systemic exposure on ritonavir plasma levels are unknown. Alternative corticosteroids which are Other corticosteroids: interaction not less dependent on CYP3A studied. Plasma concentrations of these metabolism e.g. beclomethasone medicinal products may be increased when should be considered, particularly for long term use.

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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) quetiapine (HOS-086150) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) fluticasone propionate (HOS-086331) carvedilol (HOS-115322) risperidone (HOS-086280) amlodipine (HOS-086287) thioridazine (HOS-086281) perphenazine (HOS-116395) calcium (HOS-085615) betamethasone (HOS-090066) lead (HOS-085592) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) propionate (HOS-108915) everolimus (HOS-086310) ritonavir (HOS-084521) beclomethasone (HOS-086334) lurasidone (HOS-086148) irinotecan (HOS-112102) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)